2011 Nobel Prize in Chemistry: 'Quasicrystals' once thought impossible have changed understanding of solid matter

ScienceDaily (Oct. 5, 2011) — The Royal Swedish Academy of Sciences has decided to award the Nobel Prize in Chemistry for 2011 to Daniel Shechtman of the Technion -- Israel Institute of Technology in Haifa, Israel, for the discovery of quasicrystals: non-repeating regular patterns of atoms that were once thought to be impossible.

A remarkable mosaic of atoms

In quasicrystals, we find the fascinating mosaics of the Arabic world reproduced at the level of atoms: regular patterns that never repeat themselves. However, the configuration found in quasicrystals was considered impossible, and Daniel Shechtman had to fight a fierce battle against established science. The Nobel Prize in Chemistry 2011 recognizes a breakthrough that has fundamentally altered how chemists conceive of solid matter.

On the morning of April 8, 1982, an image counter to the laws of nature appeared in Daniel Shechtman's electron microscope. In all solid matter, atoms were believed to be packed inside crystals in symmetrical patterns that were repeated periodically over and over again. For scientists, this repetition was required in order to obtain a crystal.

Shechtman's image, however, showed that the atoms in his crystal were packed in a pattern that could not be repeated. Such a pattern was considered just as impossible as creating a football using only six-cornered polygons, when a sphere needs both five- and six-cornered polygons. His discovery was extremely controversial. In the course of defending his findings, he was asked to leave his research group. However, his battle eventually forced scientists to reconsider their conception of the very nature of matter.

Aperiodic mosaics, such as those found in the medieval Islamic mosaics of the Alhambra Palace in Spain and the Darb-i Imam Shrine in Iran, have helped scientists understand what quasicrystals look like at the atomic level. In those mosaics, as in quasicrystals, the patterns are regular -- they follow mathematical rules -- but they never repeat themselves.

When scientists describe Shechtman's quasicrystals, they use a concept that comes from mathematics and art: the golden ratio. This number had already caught the interest of mathematicians in Ancient Greece, as it often appeared in geometry. In quasicrystals, for instance, the ratio of various distances between atoms is related to the golden mean.

Following Shechtman's discovery, scientists have produced other kinds of quasicrystals in the lab and discovered naturally occurring quasicrystals in mineral samples from a Russian river. A Swedish company has also found quasicrystals in a certain form of steel, where the crystals reinforce the material like armor. Scientists are currently experimenting with using quasicrystals in different products such as frying pans and diesel engines.

Daniel Shechtman, Israeli citizen. Born 1941 in Tel Aviv, Israel. Ph.D. 1972 from Technion -- Israel Institute of Technology, Haifa, Israel. Distinguished Professor, The Philip Tobias Chair, Technion -- Israel Institute of Technology, Haifa, Israel.

The Prize amount: SEK 10 million.

For further information, including backgrounders for the public and scientists and links for further reading, see: http://www.nobelprize.org/nobel_prizes/chemistry/laureates/2011/press.html

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Scientists a step closer to understanding 'natural antifreeze' molecules

ScienceDaily (June 23, 2011) — Scientists have made an important step forward in their understanding of cryoprotectants -- compounds that act as natural 'antifreeze' to protect drugs, food and tissues stored at sub-zero temperatures.

Researchers from the Universities of Leeds and Illinois, and Columbia University in New York, studied a particular type of cryoprotectants known as osmolytes. They found that small osmolyte molecules are better at protecting proteins than larger ones.

The findings, published in Proceedings of the National Academy of Sciences, could help scientists develop better storage techniques for a range of materials, including human reproductive tissue used in IVF.

Biological systems can usually only operate within a small range of temperatures. If they get too hot or too cold, the molecules within the system can become damaged (denatured), which affects their structure and stops them from functioning.

But certain species of fish, reptiles and amphibians can survive for months below freezing by entering into a kind of suspended animation. They are able to survive these extreme conditions thanks to osmolytes -- small molecules within their blood that act like antifreeze -preventing damage to their vital organs.

These properties have made osmolytes attractive to scientists. They are used widely in the storage and testing of drugs and other pharmaceuticals; in food production; and to store human tissue like egg and sperm cells at very low temperatures (below -40ºC) for a long period of time.

"If you put something like human tissue straight in the freezer, ice crystals start to grow in the freezing water and solutes -- solid particles dissolved in the water -- get forced out into the remaining liquid.

This can result in unwanted high concentrations of solutes, such as salt, which can be very damaging to the tissue," said Dr Lorna Dougan from the University of Leeds, who led the study. "The addition of cryoprotectants, such as glycerol, lowers the freezing temperature of water and prevents crystallisation by producing a 'syrupy' semi-solid state. The challenge is to know which cryoprotectant molecule to use and how much of it is necessary.

"We want to get this right so that we recover as much of the biological material as possible after re-thawing. This has massive cost implications, particularly for the pharmaceutical industry because at present they lose a large proportion of their viable drug every time they freeze it."

Dr Dougan and her team tested a range of different osmolytes to find out which ones are most effective at protecting the 3D structure of a protein. They used an atomic force microscope to unravel a test protein in a range of different osmolyte environments to find out which ones were most protective. They discovered that smaller molecules, such as glycerol, are more effective than larger ones like sorbitol and sucrose.

Dr Dougan said: "We've been able to show that if you want to really stabilise a protein, it makes sense to use small protecting osmolytes. We hope to use this discovery and future research to develop a simple set of rules that will allow scientists and industry to use the best process parameters for their system and in doing so dramatically increase the amount of material they recover from the freeze-thaw cycle."

The research was funded by the UK Engineering and Physical Sciences Research Council, the US National Institutes of Health and the China National Basic Research Program.

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The above story is reprinted (with editorial adaptations by ScienceDaily staff) from materials provided by University of Leeds.

Journal Reference:

L. Dougan, G. Z. Genchev, H. Lu, J. M. Fernandez. Probing osmolyte participation in the unfolding transition state of a protein. Proceedings of the National Academy of Sciences, 2011; DOI: 10.1073/pnas.1101934108

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Quantum knowledge cools computers: New understanding of entropy

ScienceDaily (June 1, 2011) — From a laptop warming a knee to a supercomputer heating a room, the idea that computers generate heat is familiar to everyone. But theoretical physicists have discovered something astonishing: not only do computational processes sometimes generate no heat, under certain conditions they can even have a cooling effect. Behind this finding are fundamental considerations relating to knowledge and a lack of knowledge. The researchers publish their findings in the journal Nature.

When computers compute, the energy they consume eventually ends up as heat. This isn't all due to the engineering of the computer -- physics has something to say about the fundamental energy cost of processing information.

Recent research by a team of physicists reveals a surprise at this fundamental level. ETH-Professor Renato Renner, and Vlatko Vedral of the Centre for Quantum Technologies at the National University of Singapore and the University of Oxford, UK, and their colleagues describe in the scientific journal Nature how the deletion of data, under certain conditions, can create a cooling effect instead of generating heat. The cooling effect appears when the strange quantum phenomenon of entanglement is invoked. Ultimately, it may be possible to harness this effect to cool supercomputers that have their performance held back by heat generation. "Achieving the control at the quantum level that would be required to implement this in supercomputers is a huge technological challenge, but it may not be impossible. We have seen enormous progress is quantum technologies over the past 20 years," says Vedral. With the technology in quantum physics labs today, it should be possible to do a proof of principle experiment on a few bits of data.

Landauer's principle is given a quantum twist

The physicist Rolf Landauer calculated back in 1961 that during the deletion of data, some release of energy in the form of heat is unavoidable. Landauer's principle implies that when a certain number of arithmetical operations per second have been exceeded, the computer will produce so much heat that the heat is impossible to dissipate. In supercomputers today other sources of heat are more significant, but Renner thinks that the critical threshold where Landauer's erasure heat becomes important may be reached within the next 10 to 20 years. The heat emission from the deletion of a ten terabyte hard-drive amounts in principle to less than a millionth of a joule. However, if such a deletion process were repeated many times per second then the heat would accumulate correspondingly.

The new study revisits Landauer's principle for cases when the values of the bits to be deleted may be known. When the memory content is known, it should be possible to delete the bits in such a manner that it is theoretically possible to re-create them. It has previously been shown that such reversible deletion would generate no heat. In the new paper, the researchers go a step further. They show that when the bits to be deleted are quantum-mechanically entangled with the state of an observer, then the observer could even withdraw heat from the system while deleting the bits. Entanglement links the observer's state to that of the computer in such a way that they know more about the memory than is possible in classical physics.

Similar formulas -- two disciplines

In order to reach this result, the scientists combined ideas from information theory and thermodynamics about a concept known as entropy. Entropy appears differently in these two disciplines, which are, to a large extent, independent of each other. In information theory, entropy is a measurement of the information density. It describes, for instance, how much memory capacity a given set of data would take up when compressed optimally. In thermodynamics, on the other hand, entropy relates to the disorder in systems, for example to the arrangement of molecules in a gas. In thermodynamics, adding entropy to a system is usually equivalent to adding energy as heat.

The ETH physicist Renner says "We have now shown that in both cases, the term entropy is actually describing the same thing even in the quantum mechanical regime." As the formulas for the two entropies look the same, it had already been assumed that there was a connection between them. "Our study shows that in both cases, entropy is considered to be a type of lack of knowledge," says Renner. The new paper in Nature builds on work published earlier in the New Journal of Physics.

In measuring entropy, one should bear in mind that an object does not have a certain amount of entropy per se, instead an object's entropy is always dependent on the observer. Applied to the example of deleting data, this means that if two individuals delete data in a memory and one has more knowledge of this data, she perceives the memory to have lower entropy and can then delete the memory using less energy. Entropy in quantum physics has the unusual property of sometimes being negative when calculated from the information theory point of view. Perfect classical knowledge of a system means the observer perceives it to have zero entropy. This corresponds to the memory of the observer and that of the system being perfectly correlated, as much as allowed in classical physics. Entanglement gives the observer „more than complete knowledge" because quantum correlations are stronger than classical correlations. This leads to an entropy less than zero. Until now, theoretical physicists had used this negative entropy in calculations without understanding what it might mean in thermodynamic terms or experimentally.

No heat, even a cooling effect

In the case of perfect classical knowledge of a computer memory (zero entropy), deletion of the data requires in theory no energy at all. The researchers prove that "more than complete knowledge" from quantum entanglement with the memory (negative entropy) leads to deletion of the data being accompanied by removal of heat from the computer and its release as usable energy. This is the physical meaning of negative entropy.

Renner emphasizes, however, "This doesn't mean that we can develop a perpetual motion machine." The data can only be deleted once, so there is no possibility to continue to generate energy. The process also destroys the entanglement, and it would take an input of energy to reset the system to its starting state. The equations are consistent with what's known as the second law of thermodynamics: the idea that the entropy of the universe can never decrease. Vedral says "We're working on the edge of the second law. If you go any further, you will break it."

Fundamental findings

The scientists' new findings relating to entropy in thermodynamics and information theory may have usefulness beyond calculating the heat production of computers. For example, methods developed within information theory to handle entropy could lead to innovations in thermodynamics. The connection made between the two concepts of entropy is fundamental.

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The above story is reprinted (with editorial adaptations by ScienceDaily staff) from materials provided by ETH Zurich/Swiss Federal Institute of Technology.

Journal Reference:

Lídia del Rio, Johan Åberg, Renato Renner, Oscar Dahlsten, Vlatko Vedral. The thermodynamic meaning of negative entropy. Nature, 2011; 474 (7349): 61 DOI: 10.1038/nature10123

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Understanding how crops deal with stress -- yield's biggest enemy

ScienceDaily (Apr. 25, 2011) — Like people, plants experience stress. And also, like people, the response to that stress can determine success.

People can exercise, or rest, or talk about the problem.

For plants, ways to deal with stress are internal. And ISU researchers are trying to understand how they do it.

Stephen Howell is a professor of genetics, development and cell biology and former director of the Plant Sciences Institute at ISU. His research is featured in the current issue of the Proceedings of the National Academy of Sciences.

"We've discovered a new arm of the pathway by which plants activate a response to environmental stress," he said.

Adverse environmental conditions, such as drought, flood, heat and other stresses, affect yield more than crop pests and diseases. Finding a way to maintain high yields for plants under stress is a goal of plant breeders and other agriculture stakeholders, said Howell.

"These are environmental stresses that the farmers can't control," Howell said. "They are acts of nature. And now seed companies are interested in trying to equip plants with the ability to tolerate stress."

Plant cells produce proteins and ship them to different parts of the cell. During production and shipment, these proteins move through an area of the cell called the endoplasmic reticulum (ER).

Under normal conditions, these proteins are folded into their normal, healthy three-dimensional structures as they are produced.

When a plant is under stress, its cells produce poorly folded or unfolded proteins. Inside the ER, a built-in, quality-control system senses this and "sets off an alarm in the cell," said Howell.

In response to the alarm, another protein (IRE1) cuts apart an important RNA molecule, but then splices it back together to create a different sequence.

This cut-and-splice event activates a cascade of stress response genes whose products bring about internal defensive measures that help the plant survive.

"As it turns out, responses that are activated under stress conditions actually inhibit the growth of plants," said Howell. "This allows them to conserve their energy to survive the stress conditions."

For plants in the wild, this response is a survival tactic, he said.

In production agriculture crops, however, these responses reduce yields.

"You don't want crop plants to [stop growing]," Howell said. "You want them to continue to grow and produce even though they are under stress."

With the new understanding of this stress response pathway, Howell says, the next step may be to silence the alarm system.

"What may be important is to disable some of these stress responses," said Howell. "That may make the plant be more productive under stress conditions."

Howell's research team included Yan Deng and Renu Srivastava, both of the Plant Sciences Institute, Ames; Sabrina Humbert and Steven Rothstein, both of University of Guelph, Canada; and Jian-Xiang Liu formerly of the Plant Sciences Institute and now a faculty member at Fudan University, China.

Howell is currently on leave from ISU and is director of the Division of Molecular and Cellular Biosciences for the National Science Foundation in Washington, D.C.

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The above story is reprinted (with editorial adaptations by ScienceDaily staff) from materials provided by Iowa State University.

Journal Reference:

Yan Deng, Sabrina Humbert, Jian-Xiang Liu, Renu Srivastava, Steven J. Rothstein, and Stephen H. Howell. Heat induces the splicing by IRE1 of a mRNA encoding a transcription factor involved in the unfolded protein response in Arabidopsis. Proceedings of the National Academy of Sciences, 2011; DOI: 10.1073/pnas.1102117108

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